Physician & Postdoctoral Researcher
PLA General Hospital, First Medical Center
Specializing in Pathogenic Biology & Toxicology Research
I am a physician and postdoctoral researcher at PLA General Hospital First Medical Center, with extensive expertise in pathogenic biology and toxicology research.
My research focuses on understanding the molecular mechanisms of drug-induced organ toxicity, particularly kidney and liver damage. Using advanced metabolomics and lipidomics approaches, I investigate how toxic substances affect cellular metabolism and identify potential therapeutic targets for preventing organ injury.
With a Ph.D. in Pathogenic Biology from Guizhou Medical University and clinical training at Chengdu University of Traditional Chinese Medicine, I bring a unique perspective that bridges traditional medicine knowledge with modern molecular biology techniques.
Research Focus: Drug-induced organ toxicity and metabolic mechanisms
Dissertation: Metabolomic analysis of cantharidin-induced nephrotoxicity
Thesis: Mechanisms of drug-induced toxicity using integrative approaches
5-year medical program with clinical training
January 2025 - Present
Funding Agency: Beijing Natural Science Foundation (Youth Project)
Grant Number: 7254489
Amount: 200,000 CNY
Focus: Single-cell sequencing approach to study ginseng total saponins' mechanism in preventing acute kidney injury through adaptogen-tonic-mitochondrial homeostasis pathway
January 2022 - December 2022
Funding Agency: Guizhou Province Graduate Research Fund
Grant Number: Qian Jiao He YJSKYJJ [2021] 154
Amount: 20,000 CNY
Status: Completed
Focus: Metabolomics-based investigation of cantharidin nephrotoxicity mechanisms in mice
January 2021 - December 2024
Funding Agency: National Natural Science Foundation of China (Regional Science Fund)
Grant Number: 82060754
Amount: 340,000 CNY
Status: Completed
Focus: Investigating cantharidin-induced liver injury through lipid markers, metabolic pathways, and key metabolic enzymes
All publications listed below are first-author papers in international peer-reviewed journals
Journal of Pharmaceutical Analysis, 2025
Utilized integrative lipidomics and spatial metabolomics to reveal phospholipid metabolism disorders in kidney damage
Environmental Pollution, 2024, 349: 123949
Demonstrated arsenic's impact on kidney metabolism through functional metabolomics approach
Food and Chemical Toxicology, 2023, 171: 113541
Combined metabolomics and network pharmacology to analyze kidney biometabolic processes
Food and Chemical Toxicology, 2022, 163: 112986
Revealed the role of ER stress in cantharidin-induced kidney damage mechanisms
Food and Chemical Toxicology, 2020, 146: 111845
Pioneering application of untargeted metabolomics to understand cantharidin nephrotoxicity at cellular level
I'm always open to discussing research collaborations, academic opportunities, or exchanges in the field of toxicology and metabolomics research.
PLA General Hospital, First Medical Center
Physician & Postdoctoral Researcher
Pathogenic Biology, Toxicology, Metabolomics
Metabolomics
Toxicology
Molecular Biology