Tianmu He

Physician & Postdoctoral Researcher

PLA General Hospital, First Medical Center
Specializing in Pathogenic Biology & Toxicology Research

About Me

I am a physician and postdoctoral researcher at PLA General Hospital First Medical Center, with extensive expertise in pathogenic biology and toxicology research.

My research focuses on understanding the molecular mechanisms of drug-induced organ toxicity, particularly kidney and liver damage. Using advanced metabolomics and lipidomics approaches, I investigate how toxic substances affect cellular metabolism and identify potential therapeutic targets for preventing organ injury.

With a Ph.D. in Pathogenic Biology from Guizhou Medical University and clinical training at Chengdu University of Traditional Chinese Medicine, I bring a unique perspective that bridges traditional medicine knowledge with modern molecular biology techniques.

5
First-Author Papers
3
Research Grants
2024
Postdoc Start
Cute hamster

Education

August 2024 - Present

Postdoctoral Researcher

PLA General Hospital, First Medical Center

Research Focus: Drug-induced organ toxicity and metabolic mechanisms

September 2021 - July 2024

Ph.D. in Pathogenic Biology

Guizhou Medical University

Dissertation: Metabolomic analysis of cantharidin-induced nephrotoxicity

September 2018 - June 2021

Master's Degree in Pathogenic Biology

Zunyi Medical University

Thesis: Mechanisms of drug-induced toxicity using integrative approaches

September 2013 - June 2018

Bachelor of Medicine in Clinical Medicine

Chengdu University of Traditional Chinese Medicine

5-year medical program with clinical training

Research Projects

Ginseng Total Saponins in Acute Kidney Injury Prevention

Principal Investigator

January 2025 - Present

Funding Agency: Beijing Natural Science Foundation (Youth Project)

Grant Number: 7254489

Amount: 200,000 CNY

Focus: Single-cell sequencing approach to study ginseng total saponins' mechanism in preventing acute kidney injury through adaptogen-tonic-mitochondrial homeostasis pathway

Cantharidin-Induced Nephrotoxicity Mechanism Study

Principal Investigator

January 2022 - December 2022

Funding Agency: Guizhou Province Graduate Research Fund

Grant Number: Qian Jiao He YJSKYJJ [2021] 154

Amount: 20,000 CNY

Status: Completed

Focus: Metabolomics-based investigation of cantharidin nephrotoxicity mechanisms in mice

Cantharidin-Induced Liver Injury Molecular Mechanism

Co-Investigator

January 2021 - December 2024

Funding Agency: National Natural Science Foundation of China (Regional Science Fund)

Grant Number: 82060754

Amount: 340,000 CNY

Status: Completed

Focus: Investigating cantharidin-induced liver injury through lipid markers, metabolic pathways, and key metabolic enzymes

Representative Publications

All publications listed below are first-author papers in international peer-reviewed journals

First Author

Disorder of phospholipid metabolism in the renal cortex and medulla contributes to acute tubular necrosis in mice after cantharidin exposure using integrative lipidomics and spatial metabolomics

Tianmu He, Kexin Lin, Lijuan Xiong, Wen Zhang, Huan Zhang, Cancan Duan, Xiaofei Li, Jianyong Zhang

Journal of Pharmaceutical Analysis, 2025

Utilized integrative lipidomics and spatial metabolomics to reveal phospholipid metabolism disorders in kidney damage

First Author

Functional metabolomics reveals arsenic-induced inhibition of linoleic acid metabolism in mice kidney in drinking water

Tianmu He, Lijuan Xiong, Kexin Lin, Jing Yi, Cancan Duan, Jianyong Zhang

Environmental Pollution, 2024, 349: 123949

Demonstrated arsenic's impact on kidney metabolism through functional metabolomics approach

First Author

Mice kidney biometabolic process analysis after cantharidin exposure using widely-targeted metabolomics combined with network pharmacology

Tianmu He, Lijuan Xiong, Yixin Zhang, Rong Yan, Ming Yu, Meichen Liu, Liu Liu, Cancan Duan, Xiaofei Li, Jianyong Zhang

Food and Chemical Toxicology, 2023, 171: 113541

Combined metabolomics and network pharmacology to analyze kidney biometabolic processes

First Author

Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity

Tianmu He, Qiyi Wang, Jingwen Ao, Kuan Chen, Xiaofei Li, Jianyong Zhang, Cancan Duan

Food and Chemical Toxicology, 2022, 163: 112986

Revealed the role of ER stress in cantharidin-induced kidney damage mechanisms

First Author

Analysis of cantharidin-induced nephrotoxicity in HK-2 cells using untargeted metabolomics and an integrative network pharmacology analysis

Tianmu He, Jingxian Liu, Xiaoning Wang, Cancan Duan, Xiaofei Li, Jianyong Zhang

Food and Chemical Toxicology, 2020, 146: 111845

Pioneering application of untargeted metabolomics to understand cantharidin nephrotoxicity at cellular level

Contact

Let's Connect

I'm always open to discussing research collaborations, academic opportunities, or exchanges in the field of toxicology and metabolomics research.

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Institution

PLA General Hospital, First Medical Center

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Position

Physician & Postdoctoral Researcher

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Research Focus

Pathogenic Biology, Toxicology, Metabolomics

Research Interests

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Metabolomics

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Toxicology

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Molecular Biology